Tobias Krammer

TREM2 drives accumulation of pro-scarring monocyte-derived macrophages in the infarcted myocardium

This study shows TREM2 drives pro-scarring macrophage accumulation in infarcted myocardium, leading to fibrosis and reduced cardiac repair.

Murine CMV Infection Unmasks Macrophage-Driven Inflammatory Cardiomyopathy in Pkp2, but not in Ttn Mutant Mice

This study shows that murine cytomegalovirus infection exacerbates inflammation in Pkp2 mutant mice but not in Ttn mutant mice, highlighting the interaction between genetic predisposition and environmental factors in cardiomyopathy.

Neutrophil terminal programming in the ischemic heart drives fibrosis after myocardial infarction

This study shows that neutrophils in the ischemic heart undergo terminal programming to drive fibrosis after myocardial infarction.

CD4+ T cells fuel the Duchenne cardiomyopathy

This study shows CD4+ T cells drive cardiomyopathy in Duchenne muscular dystrophy by promoting fibrosis and dysfunction, using Mdx mice and single-cell RNA sequencing.

Targeting platelet GPVI or GPIIb/IIIa only minimally affect acute inflammation and cardiac repair in experimental permanent myocardial infarction

Identifying Modulators of Cellular Responses by Heterogeneity-sequencing

Heterogeneity-seq identifies causal factors driving heterogeneous cellular responses by combining single-cell RNA-seq with metabolic labeling and double machine learning.

Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironment

The paper identifies the spatial organisation and regulatory mechanisms of epithelial lineages at the gastroesophageal junction using multi-omics approaches and shows that Wnt microenvironments maintain homeostasis without lineage plasticity.

scSLAM-seq reveals core features of transcription dynamics in single cells

scSLAM-seq measures transcription dynamics in single cells by distinguishing newly synthesized from pre-existing RNA, revealing stochastic transcription and gene-specific differences.