Laura Masatti

Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes

This study identifies Ackr3 as a regulator of astrocyte-mediated synaptic removal in disease, showing its role in synapse engulfment and its upregulation in Alzheimer's disease.

CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming

This study identifies CD300e as a driver of immunosuppressive tumor microenvironment in colorectal cancer by reprogramming macrophages to suppress T-cell function and promote tumor growth.

signifinder enables the identification of tumor cell states and cancer expression signatures in bulk, single-cell and spatial transcriptomic data

signifinder is an R package that collects, implements, and compares cancer-related gene expression signatures across bulk, single-cell, and spatial transcriptomic data to improve reproducibility and usability.