Adam D. Norris

The paper identifies RBM-25 as a central activator of microexon splicing in C. elegans through spatiotemporal isoform profiling and genetic screening.

The paper identifies intestinal proteolysis as the cause of smn-1 mutant phenotypes in C. elegans, showing that hyperactive proteasome activity and immune responses in the intestine drive disease.

The paper uses single-cell RNA-Seq to analyze splicing patterns in C. elegans neurons, identifying cell-specific isoforms and regulatory factors.

The paper shows PRPF40A is required for microexon splicing in mouse cells, co-regulating with SRRM4 and exhibiting distinct size-dependent behavior.

The paper identifies an ion transporter gene, nhx-6, as a causative target of RNA binding proteins exc-7 and mbl-1, whose inhibition extends lifespan in C. elegans.

The paper identifies a genetic interaction between fust-1 and tdp-1 in C. elegans, showing they co-inhibit exon inclusion and control fertility with ceh-14.

This study shows that a sas-6(L69T) mutation in C. elegans disrupts centrosome duplication, ciliogenesis, and dendrite morphogenesis, contributing to microcephaly mechanisms.

This study identifies a shared role for mec-2 and Stoml3 in olfactory behavior across C. elegans and mice, showing that they are required for odor discrimination but not odor detection.

VISTA visualizes the spatial transcriptome of C. elegans neurons using existing datasets, enabling gene expression analysis across neurons with a spatial heatmap interface.