Hyperactive intestinal proteolysis underlies smn-1 mutant phenotypes
Anusha Iyengar, Lindsey Philips, Adam D. Norris
The paper identifies intestinal proteolysis as the cause of smn-1 mutant phenotypes in C. elegans, showing that hyperactive proteasome activity and immune responses in the intestine drive disease.
bioRxiv · Aug 20, 2026 · PreprintGenetics