Wenlong Carl Chen

Genetic and Cellular Architecture of Breast Cancer Risk Across Ancestries

This study analyzes breast cancer GWAS across multiple ancestries, finding similar heritability and genetic correlations, and identifies shared regulatory and cellular contexts.

A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

This study develops a machine learning model using oral microbiome data to predict esophageal squamous cell carcinoma, showing good performance across different geographic regions.

Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

This study identifies genetic associations and evolutionary factors underlying androgenetic alopecia in African men, showing poor generalization of European genetic predictions and continental differences in allele frequencies.

FPGA Acceleration of GWAS Permutation Testing

This paper presents an FPGA-based tool for accelerating GWAS permutation testing, achieving significant speed improvements over CPU-based methods like PLINK.

Genetic Association and Transferability for Urinary Albumin-Creatinine Ratio as a Marker of Kidney Disease in four Sub-Saharan African Populations and non-continental Individuals of African Ancestry

This study conducts a GWAS on urinary albumin-to-creatinine ratio in Sub-Saharan African and non-resident African-ancestry populations, identifying two genome-wide significant loci and highlighting limited transferability of polygenic scores across populations.

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction

This study identifies 447 new genetic variants associated with prostate-specific antigen levels across multiple ancestries and shows improved cross-ancestry prediction of PSA, with implications for personalized prostate cancer screening.

A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

The paper develops a genotyping array tailored for African populations to identify cancer risk variants, finding population-specific allele frequency differences and lower prostate cancer risk in Senegal compared to Nigeria.