This study shows that better adherence to the DASH diet in midlife and early elderhood improves late-life verbal memory and brain health through structural and neurovascular mechanisms.

bioRxiv · Sep 28, 2026 · PreprintNeuroscience

Spurious model comparisons are widespread in biomedical artificial intelligence

Tianchu Zeng, Hetu Li, Shaoshi Zhang, Yan Quan Tan, Fang Tian, Csaba Orbán, Lijun An, Wanyu Che, Jingwen Cheng, Joanna Su Xian Chong, Niousha Dehestani, Zijian Dong, Xin Li, Zhizhou Li, Mervyn Jun Rui Lim, , B.T. Thomas Yeo

97% of 184 high-impact biomedical AI studies compare cross-validated models with tests assuming fold independence; in 69% of re-analyzable studies a significant comparison does not survive correction.

bioRxiv · Sep 10, 2026 · PreprintBioinformatics✦ In-depth digest

Rate of brain aging associates with future executive function in Asian children and older adults

Susan F Cheng, Wan Lin Yue, Kwun Kei Ng, Xing Qian, Siwei Liu, Trevor WK Tan, Kim‐Ngan Nguyen, Ruth L F Leong, Saima Hilal, Ching‐Yu Cheng, Ai Peng Tan, Evelyn Chung Ning Law, Peter David Gluckman, Christopher Chen, Yap Seng Chong, , Juan Helen Zhou

This study tests a brain age model on Singaporean children and elderly, finding that brain age gap change relates to future executive function in both groups.

eLife · Jun 16, 2025Peer-reviewedNeuroscience

Optimizing Biophysical Large-Scale Brain Circuit Models With Deep Neural Networks

Tianchu Zeng, Tian Fang, Shaoshi Zhang, Xin Li, Ai Peng Tan, Bart Larsen, Sina Mansour L., Fang Ji, Joanna Su Xian Chong, Kwong Hsia Yap, Christopher Chen, Nicolai Franzmeier, Sebastian N. Roemer-Cassiano, Sidhant Chopra, Carrisa V. Cocuzza, , B.T. Thomas Yeo

This paper introduces DELSSOME, a deep learning framework that accelerates biophysical brain circuit model optimization, enabling faster parameter estimation and lifespan trajectory analysis of cortical E/I ratios.

bioRxiv · Apr 7, 2025 · PreprintNeuroscience

DeepResBat: deep residual batch harmonization accounting for covariate distribution differences

Lijun An, Chen Zhang, Naren Wulan, Shaoshi Zhang, Pansheng Chen, Fang Ji, Kwun Kei Ng, Christopher Chen, Juan Helen Zhou, B.T. Thomas Yeo, Alzheimer’s Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle Study of Aging

DeepResBat improves MRI data harmonization by addressing covariate distribution differences, outperforming existing methods while avoiding false associations.

Medical Image Analysis · Sep 20, 2024Peer-reviewedNeuroscience

Stage dependent differential influence of metabolic and structural networks on memory across Alzheimer's disease continuum

Kok Pin Ng, Xing Qian, Kwun Kei Ng, Fang Ji, Pedro Rosa‐Neto, Serge G. Gauthier, Nagaendran Kandiah, Juan Helen Zhou, the Alzheimer’s Disease Neuroimaging Initiative

The paper examines how structural and metabolic network integrity influences memory across Alzheimer's disease stages, finding pathology-dependent changes in these relationships.

eLife · Sep 2, 2022Peer-reviewedNeuroscience