Yap Seng Chong

From Geometry to Hierarchy: Charting the Dominant Modes of Human Cortical Function Through Development

This study shows that the development of long-range cortical connections leads to the emergence of hierarchical functional modes in the human cortex, shifting from geometrically driven patterns to sensory-association organization.

Prenatal exposure to PFAS and multimodal structural brain development across childhood

This study examines the impact of prenatal PFAS exposure on childhood brain development using MRI data, finding associations with cortical surface area and white matter microstructure changes.

Developing a multi-modal neuroimaging-based BrainAge model across childhood

This paper develops and benchmarks BrainAge models using multi-modal neuroimaging data from childhood cohorts to distinguish healthy from symptomatic developmental trajectories.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

Rate of brain aging associates with future executive function in Asian children and older adults

This study tests a brain age model on Singaporean children and elderly, finding that brain age gap change relates to future executive function in both groups.

Optimizing Biophysical Large-Scale Brain Circuit Models With Deep Neural Networks

This paper introduces DELSSOME, a deep learning framework that accelerates biophysical brain circuit model optimization, enabling faster parameter estimation and lifespan trajectory analysis of cortical E/I ratios.

Short-term diet intervention alters the small non-coding RNA (sncRNA) landscape of human sperm

The paper shows diet intervention alters sncRNA expression in human sperm, linking paternal nutrition to offspring health through epigenetic changes.

A longitudinal resource for population neuroscience of school-age children and adolescents in China

The paper introduces a longitudinal dataset of school-age children and adolescents in China, detailing its design, sampling, and neuroimaging measurements.

In-vivo whole-cortex estimation of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth

The paper estimates the whole-cortex excitation-inhibition ratio using fMRI and shows it declines during youth, with lower ratios linked to better cognitive performance in children.

Homotopic local-global parcellation of the human cerebral cortex from resting-state functional connectivity

The paper develops homotopic local-global parcellations of the human cerebral cortex using resting-state and task-fMRI, showing improved homogeneity and lateralization compared to existing parcellations.

Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes

The paper defines a homeostatic inflammation signature in the placenta, creates a polygenic score, and shows its protective effects on cardiovascular and depressive outcomes using UK Biobank data.

RAPTOR: A Five-Safes approach to a secure, cloud native and serverless genomics data repository

RAPTOR provides a secure, cloud-native genomics repository with a five-safes framework to ensure compliance and data protection for genomic research.

Brain charts for the human lifespan

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk

The paper maps the developmental and intergenerational changes in the human circulatory lipidome and identifies lipid signatures associated with obesity risk in mothers and offspring.