Nicolai Franzmeier

The paper shows aging and Alzheimer's disease alter distinct functional connectivity axes in the brain, with AD affecting the sensory-association axis and aging affecting the representation-executive axis.

This study examines how mesoscale connectivity patterns in the medial temporal lobe relate to tau pathology and memory in older adults, finding distinct associations with age and AD pathology.

The paper shows that individual functional brain connectivity improves the explanation of tau PET patterns in Alzheimer's disease compared to group-level data.

The paper shows longer scans improve prediction accuracy in brain-wide association studies while reducing costs, with 30-minute scans being the most cost-effective.

This paper introduces DELSSOME, a deep learning framework that accelerates biophysical brain circuit model optimization, enabling faster parameter estimation and lifespan trajectory analysis of cortical E/I ratios.

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

This study shows that alpha-Synuclein co-pathology in Alzheimer's Disease increases tau levels, linking AD and Parkinson's Disease pathogenesis.

This study shows that neuronal and oligodendroglial tau, but not astroglial tau, contribute to tau-PET signals in 4-repeat tauopathies.

This study shows that chronic PPARγ agonist treatment increases amyloid-beta fibrillarity but improves cognition and synaptic density in mouse models.

This study shows that pre-therapeutic microglia activation and sex predict the response to chronic immunomodulation in AD mouse models using TSPO-PET.