Author

Josh Lewis Stern

University of Alabama at BirminghamORCID 0000-0002-0588-1586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Lindsay F. RizzardiiD· 2 shared Amol TandoniD· 1 shared Natalie R. GassmaniD· 1 shared Spandana Kotian· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 2 mutual co-author links

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2 shared papersCell Biology

Lindsay F. RizzardiORCID

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3 papers

Recent·Most cited

Cancer BiologyPLoS ONEPeer-reviewedJun 25, 2025

SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers

Amol Tandon, Josh Lewis Stern

This study identifies that TPM cancers are vulnerable to MEK and HDAC inhibition, which synergize to enhance apoptosis via BIM and BMF pathways.

DOI 10.1371/journal.pone.0322961

humanproteomics

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Cell BiologybioRxivPreprintSep 23, 2024

Apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2/APE2) is required for efficient expression of TERT in human embryonic stem cells.

Josh Lewis Stern, Lindsay F. Rizzardi, Natalie R. Gassman

This study shows APEX2 is essential for TERT expression in hESCs and a melanoma cell line, with APEX2 knockdown reducing telomerase activity and affecting other genes, particularly those with repetitive DNA sequences.

DOI 10.1101/2024.09.23.614488

humanbulk RNA-seq

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Cell BiologybioRxivPreprintSep 16, 2024

MEK1/2 kinases cooperate with c-Myc:MAX to prevent polycomb repression of TERT in human pluripotent stem cells

Spandana Kotian, Lindsay F. Rizzardi, Josh Lewis Stern

This study identifies MEK1/2 kinases and c-Myc:MAX as regulators of TERT transcription in hESC by preventing polycomb repression.

2 citations

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