Bingxin Lu

ISdetector maps insertion sequences and detects structural variations from short-read data with high accuracy and scalability.

The paper develops a computational cell-cycle model to quantify SV generation and unify genomic patterns from chromosomal instability.

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

CNETML infers phylogenies from spatio-temporal copy number profiles of cancer samples, handling total copy numbers and temporal data to estimate mutation rates and tree topology.