Author

Hasan Mirza

Ovarian Cancer ActionORCID 0000-0002-6460-5290Unclaimed ORCID profile · follow to get notified of new preprints

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Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Iain A. McNeishiD· 3 shared Daniel MarksiD· 2 shared Darren P. EnnisiD· 2 shared Gaia GiannoneiD· 2 shared Laura A. TookmaniD· 2 shared Aikou OkamotoiD· 1 shared Aleksandar P. IvanoviD· 1 shared Ayako KawabataiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

Iain A. McNeishORCID

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3 papers

Recent·Most cited

Spatial transcriptomic analysis reveals coordinated gene expression in ovarian clear cell carcinoma and adjacent endometriosis in UK and Japanese patients

Takafumi Kuroda, Gaia Giannone, Darren P. Ennis, Hasan Mirza, Daniel Marks, Louis Flood, Mary Sisley, Ryan Griffin, S. Desai, Jacqueline R. McDermott, Nathalie Lambie, Nei Fukasawa, Takako Kiyokawa, Masayuki Shimoda, Misato Saito, , Iain A. McNeish

This study uses spatial transcriptomics to compare gene expression in ovarian clear cell carcinoma and adjacent endometriosis across UK and Japanese patients, finding distinct transcriptional patterns by tissue compartment rather than geographic origin.

bioRxiv · Jun 2, 2026 · PreprintPathology

Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor

Daniel Marks, Edwin García, Sunil Kumar, Katie Tyson, Caroline Koch, Aleksandar P. Ivanov, Joshua B. Edel, Hasan Mirza, William Flanagan, Christopher W. Dunsby, P. M. W. French, Iain A. McNeish

This paper develops a CRISPR-engineered FRET biosensor to study PARP trapping dynamics in ovarian cancer cells and identifies reduced trapping in PARPi-resistant models.

Cell Reports Methods · Dec 30, 2025Peer-reviewedCancer Biology

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions

Zhao Cheng, Darren P. Ennis, Bingxin Lu, Hasan Mirza, Chishimba Sokota, Baljeet S. Kaur, Naveena Singh, Olivia Le Saux, Giorgia Russo, Gaia Giannone, Laura A. Tookman, Jonathan Krell, Chris P. Barnes, Jackie McDermott, Iain A. McNeish

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

The Journal of Pathology · Jul 2, 2024Peer-reviewedCancer Biology