Author

Samantha J. Thomas

Thomas Jefferson UniversityORCID 0000-0002-0610-421XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Organism:rat· 2 Research Focus:cell-cell communication· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Angelo C. LeporeiD· 4 shared David A. Jaffe· 3 shared Lan ChengiD· 3 shared Matthew B. DalvaiD· 3 shared Megan A. LyttleiD· 3 shared Pauline Michel‐FlutotiD· 3 shared Rachel E. CainiD· 3 shared Brittany A. CharsariD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersNeuroscience

Angelo C. LeporeORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intrasegmental and propriospinal pre-phrenic interneuron circuitry in intact CNS and following cervical spinal cord injury

Pauline Michel‐Flutot, Angela Harbeck, Lan Cheng, Khalil Rust, Megan A. Lyttle, Samantha J. Thomas, David A. Jaffe, Kallon Crowther, Gabriela Daszewska-Smith, George M. Smith, Shuxin Li, Angelo C. Lepore

The paper maps pre-phrenic interneuron (PP-IN) connectivity to phrenic motor neurons in uninjured and injured spinal cord, revealing intrasegmental and propriospinal pathways and their plasticity after injury.

bioRxiv · Sep 14, 2026 · PreprintNeuroscience

Neuronal EphB2 signaling drives persistent neuropathic pain following spinal cord injury

Nicolette M. Heinsinger, David A. Jaffe, Kolluru D. Srikanth, Megan A. Lyttle, Madison S. Smith, Samantha J. Thomas, Brittany A. Charsar, Lan Cheng, Pauline Michel‐Flutot, Rachel E. Cain, Jaime L. Watson, Duran Bao, Jia Fan, Aditi Falnikar, Wei Zhou, , Angelo C. Lepore

This study identifies EphB2 signaling in neurons as a mechanism maintaining neuropathic pain after spinal cord injury.

bioRxiv · Apr 22, 2026 · PreprintNeuroscience

Nano-organization of synapses defines synaptic release properties at cortical neuron dendritic spines

Haani Jafri, Samantha J. Thomas, Sung Hoon Yang, Rachel E. Cain, Matthew B. Dalva

The paper investigates the nanoarchitecture of synapses and finds that nanomodules define synaptic release sites and influence the pattern of miniature synaptic responses.

bioRxiv · Feb 13, 2025 · PreprintNeuroscience

PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury

Pauline Michel‐Flutot, Lan Cheng, Samantha J. Thomas, Brianna Lisi, Harrison Schwartz, Sandy Lam, Megan A. Lyttle, David A. Jaffe, George M. Smith, Shuxin Li, Megan C. Wright, Angelo C. Lepore

This study shows that PTEN inhibition promotes partial diaphragm function recovery and axon growth in chronic cervical spinal cord injury, while PTPσ inhibition does not.

bioRxiv · Jan 10, 2024Neuroscience

EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

Mark W. Urban, Brittany A. Charsar, Nicolette M. Heinsinger, Shashirekha S. Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V. Brown, Nathan T. Henderson, Samantha J. Thomas, Biswarup Ghosh, Rachel E. Cain, Davide Trotti, Piera Pasinelli, Megan C. Wright, Matthew B. Dalva, Angelo C. Lepore

This study shows that reducing ephrinB2 in spinal cord astrocytes of ALS mice preserves diaphragm innervation and respiratory function.

eLife · Jul 17, 2023Peer-reviewedNeuroscience