Angelo C. Lepore

This study shows that PTEN inhibition improves forelimb motor recovery and circuit remodeling in chronic cervical SCI by enhancing spinal interneuron network recruitment and synaptic input.

The paper maps pre-phrenic interneuron (PP-IN) connectivity to phrenic motor neurons in uninjured and injured spinal cord, revealing intrasegmental and propriospinal pathways and their plasticity after injury.

This study identifies EphB2 signaling in neurons as a mechanism maintaining neuropathic pain after spinal cord injury.

This study identifies SM/J mice as a model for spontaneous disc herniations and shows neuroimmune changes drive chronic discogenic pain.

This study shows that PTEN inhibition promotes partial diaphragm function recovery and axon growth in chronic cervical spinal cord injury, while PTPσ inhibition does not.

This study shows that reducing ephrinB2 in spinal cord astrocytes of ALS mice preserves diaphragm innervation and respiratory function.

This study shows that astrocytic expression of mutant FUS causes TNF-dependent neurodegeneration in ALS, highlighting a therapeutic target.