Author

Megan C. Wright

Arcadia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Angelo C. LeporeiD· 2 shared Samantha J. ThomasiD· 2 shared Ahmet HökeiD· 1 shared Andrés Fuentes-FloresiD· 1 shared Birgit SchillingiD· 1 shared Biswarup GhoshiD· 1 shared Brianna LisiiD· 1 shared Brittany A. CharsariD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Angelo C. LeporeORCID

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3 papers

Recent·Most cited

PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury

Pauline Michel‐Flutot, Lan Cheng, Samantha J. Thomas, Brianna Lisi, Harrison Schwartz, Sandy Lam, Megan A. Lyttle, David A. Jaffe, George M. Smith, Shuxin Li, Megan C. Wright, Angelo C. Lepore

This study shows that PTEN inhibition promotes partial diaphragm function recovery and axon growth in chronic cervical spinal cord injury, while PTPσ inhibition does not.

bioRxiv · Jan 10, 2024Neuroscience

EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

Mark W. Urban, Brittany A. Charsar, Nicolette M. Heinsinger, Shashirekha S. Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V. Brown, Nathan T. Henderson, Samantha J. Thomas, Biswarup Ghosh, Rachel E. Cain, Davide Trotti, Piera Pasinelli, Megan C. Wright, Matthew B. Dalva, Angelo C. Lepore

This study shows that reducing ephrinB2 in spinal cord astrocytes of ALS mice preserves diaphragm innervation and respiratory function.

eLife · Jul 17, 2023Peer-reviewedNeuroscience

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

Andrés Fuentes-Flores, Cristian Gerónimo‐Olvera, David Ñecuñir, Sandip Kumar Patel, Joanna Bons, Megan C. Wright, Daniel H. Geschwind, Ahmet Höke, Jose Antonio Gomez-Sanchez, Birgit Schilling, Judith Campisi, Felipe A. Court

This study shows that senescent Schwann cells, induced by aging and chronic denervation, impair axonal regeneration by reducing c-Jun expression and secreting inhibitory factors, and that eliminating these cells improves regeneration.

bioRxiv · Dec 7, 2022 · PreprintNeuroscience