Botir T. Sagdullaev

This study investigates RS1 deficiency in mice, identifying aberrant neuro-glial activity and signaling disruptions that may inform therapeutic strategies for XLRS.

The paper uses AAV-BR1 to target endothelial cells in the mouse retina, identify their morphology, and deliver Cx43 for studying microvascular function.

The paper uses mouse retinal models to characterize pericyte diversity and demonstrate targeted control of capillary blood flow through optogenetic manipulation.

The paper investigates how pericyte and endothelial cell connectivity mediates neurovascular coupling, finding directional vasomotor responses and disrupted connectivity in diabetes.

This study identifies lysine succinylation as a post-translational modification linked to amyloid and tau pathology in Alzheimer's disease through human brain and mouse model analyses.