Author

Diana M. Acosta

The Ohio State UniversityORCID 0000-0001-5902-913XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Cankun WangiD· 2 shared Hongjun FuiD· 2 shared Qin MaiD· 2 shared Anjun MaiD· 1 shared Botir T. SagdullaeviD· 1 shared Chintda SantiskulvongiD· 1 shared Cody T. MorrisoniD· 1 shared David EliezeriD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Cankun WangORCID

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Author profile →

3 papers

Recent·Most cited

A Single-cell and Spatial RNA-seq Database for Alzheimer's Disease (ssREAD)

Cankun Wang, Diana M. Acosta, Megan E. McNutt, Jiang Bian, Anjun Ma, Hongjun Fu, Qin Ma

ssREAD is a database that compiles single-cell and spatial RNA-seq data for Alzheimer's Disease, offering analysis tools for integrative studies.

Nature Communications · Jun 6, 2024Peer-reviewedBioinformatics

Spatially resolved transcriptomics reveals unique gene signatures associated with human temporal cortical architecture and Alzheimer's pathology

Shuo Chen, Yuzhou Chang, Liangping Li, Diana M. Acosta, Yang Li, Qi Guo, Cankun Wang, Emir Turkes, Cody T. Morrison, Dominic L. Julian, Mark E. Hester, Douglas W. Scharre, Chintda Santiskulvong, Sarah XueYing Song, Jasmine Plummer, , Hongjun Fu

This study uses spatial transcriptomics to identify gene signatures in the human temporal cortex linked to Alzheimer's pathology.

Acta Neuropathologica Communications · Dec 21, 2022Peer-reviewedNeuroscience

Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology

Yun Yang, Vı́ctor Tapias, Diana M. Acosta, Hui Xu, Huan‐Lian Chen, Ruchika P. Bhawal, Elizabeth Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram H. Haroutunian, M. Flint Beal, , Gary E. Gibson

This study identifies lysine succinylation as a post-translational modification linked to amyloid and tau pathology in Alzheimer's disease through human brain and mouse model analyses.

bioRxiv · Sep 16, 2019 · PreprintNeuroscience