Apc truncation enforces optimal Wnt signalling during early intestinal tumourigenesis
Milou S. van Driel, Nina E. de Groot, Sander R. van Hooff, Jan Köster, Louis Vermeulen, Sanne M. van Neerven
This study shows that specific Apc mutations modulate Wnt signaling activity in intestinal organoids, with optimal Wnt levels selected through additional mutations and associated transcriptional and metabolic changes.
bioRxiv · Feb 12, 2026 · PreprintCancer Biology