Sander R. van Hooff

This paper introduces a microscopy-based method to measure tumour-specific viability in neuroblastoma co-cultures and patient samples, enabling more accurate drug response assessment.

This study compares ex vivo short-term, organoid, and PDX drug screening methods in neuroblastoma, finding ex vivo screens are faster and more consistent with in vivo results.

This study shows that specific Apc mutations modulate Wnt signaling activity in intestinal organoids, with optimal Wnt levels selected through additional mutations and associated transcriptional and metabolic changes.

The paper evaluates deconvolution methods for bulk RNA-Seq using scnRNA-Seq data, identifies biases, and introduces SQUID, a method that outperforms others in predicting cell mixtures and identifying cancer subclones.

The paper introduces NanoClassifier, a NanoString-based CMS classifier for CRC samples, showing strong accuracy in predicting CMS subtypes from FFPE and FF tumors.