Author

Sanne M. van Neerven

Amsterdam UMC Location University of AmsterdamORCID 0000-0003-2599-5756Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Jan KösteriD· 1 shared Louis VermeuleniD· 1 shared Milou S. van DrieliD· 1 shared Nina E. de GrootiD· 1 shared Sander R. van HooffiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

Jan KösterORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 12, 2026

Apc truncation enforces optimal Wnt signalling during early intestinal tumourigenesis

Milou S. van Driel, Nina E. de Groot, Sander R. van Hooff…·Sanne M. van Neerven

This study shows that specific Apc mutations modulate Wnt signaling activity in intestinal organoids, with optimal Wnt levels selected through additional mutations and associated transcriptional and metabolic changes.

DOI 10.64898/2026.02.11.705236

mousebulk RNA-seq

𝕏 PostBluesky