Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context
Sung Yun Park, Arlo Sheridan, Bobae An, Erin Jarvis, Julia Lyudchik, William Patton, Jun Y. Axup, Stephanie Chan, Hugo G.J. Damstra, Daniel Leible, Kylie S. Leung, Clarence A. Magno, Aashir Meeran, Julia M. Michalska, Franz Rieger, , Andrew C. Payne
The paper introduces PRISM, a platform that uses combinatorial protein barcodes to enable self-correcting neuron tracing with molecular context, improving tracing accuracy and handling spatial gaps.
bioRxiv · Sep 26, 2025 · PreprintNeuroscience