Author

Daniel Leible

Broad InstituteORCID 0009-0006-5491-6673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Edward S. BoydeniD· 3 shared Bobae AniD· 2 shared George McDonald ChurchiD· 2 shared Aashir MeeraniD· 1 shared Abhishek Sampath KumariD· 1 shared Adam Henry MarblestoneiD· 1 shared Agnese GraziosiiD· 1 shared Aine Ni Scannail· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersNeuroscience

Edward S. BoydenORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 1, 2025

Human brain organoids record the passage of time over multiple years in culture

Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei…·Paola Arlotta

This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.

14 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 26, 2025

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context

Sung Yun Park, Arlo Sheridan, Bobae An…·Andrew C. Payne

The paper introduces PRISM, a platform that uses combinatorial protein barcodes to enable self-correcting neuron tracing with molecular context, improving tracing accuracy and handling spatial gaps.

6 citations

mousespatial transcriptomics

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NeurosciencebioRxivPreprintSep 5, 2023

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao…·Li‐Huei Tsai

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

10 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 31, 2022

Expansion Sequencing of RNA Barcoded Neurons in the Mammalian Brain: Progress and Implications for Molecularly Annotated Connectomics

Daniel Goodwin, Alex Vaughan, Daniel Leible…·Richie E. Kohman

The paper introduces ExBarSeq, a method for high-resolution multiplexing of barcodes and synaptic proteins in neurons, demonstrating its application in mouse brain tissue.

2 citations

mousespatial transcriptomics

𝕏 PostBluesky