An inhibitor-interaction intermediate of HIV-1 protease, revealed by Isothermal Titration Calorimetry and NMR spectroscopy
Shahid N Khan, John D Persons, Michel Guerrero, Tatiana V. Ilina, Masayuki Oda, Rieko Ishima
The paper investigates entropy-enthalpy compensation in HIV-1 protease mutants using ITC and NMR, revealing an inhibitor-bound intermediate pathway.
bioRxiv · Sep 4, 2018 · PreprintBiochemistry