Author

Xiaochuan Sun

Peking Union Medical College HospitalORCID 0000-0002-0666-9886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Haoyi ZhengiD· 2 shared Huichun ZhaniD· 2 shared Fangfang ZhangiD· 1 shared Kirsten Zheng· 1 shared Kyla Masarik· 1 shared Xiaoxi YangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersPathology

Haoyi ZhengORCID

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2 papers

Recent·Most cited

Characterization of Congestive Heart Failure Phenotype in a Murine Model of JAK2V617F-positive Myeloproliferative Neoplasm

Xiaochuan Sun, Haoyi Zheng, Huichun Zhan

This study characterizes heart failure in Tie2FF1 mice, showing left ventricular dilation, microvascular remodeling, and pulmonary/hepatic congestion without obstructive coronary disease.

bioRxiv · Sep 30, 2026 · PreprintPathology

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular Disease

Xiaoxi Yang, Kyla Masarik, Xiaochuan Sun, Fangfang Zhang, Kirsten Zheng, Haoyi Zheng, Huichun Zhan

This study shows that JAK2V617F-mutant hematopoiesis causes cardiac microvascular disease, and blocking MPL signaling in endocardial endothelial cells improves cardiac function.

bioRxiv · Apr 3, 2026 · PreprintCell Biology