Author

Xiaoxi Yang

Peking Union Medical College HospitalORCID 0000-0002-2674-1902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Huichun ZhaniD· 2 shared Kyla Masarik· 2 shared Bowei YaniD· 1 shared Fangfang ZhangiD· 1 shared Haoyi ZhengiD· 1 shared Kirsten Zheng· 1 shared Lei ZhengiD· 1 shared Lianlian WuiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Huichun ZhanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular Disease

Xiaoxi Yang, Kyla Masarik, Xiaochuan Sun, Fangfang Zhang, Kirsten Zheng, Haoyi Zheng, Huichun Zhan

This study shows that JAK2V617F-mutant hematopoiesis causes cardiac microvascular disease, and blocking MPL signaling in endocardial endothelial cells improves cardiac function.

bioRxiv · Apr 3, 2026 · PreprintCell Biology

The Immune-Modulatory Function of Megakaryocytes in the Hematopoietic Niche of Myeloproliferative Neoplasms

Sandy Lee, Xiaoxi Yang, Kyla Masarik, Tameena Ahmed, Lei Zheng, Huichun Zhan

This study shows that JAK2V617F mutant megakaryocytes drive immune dysregulation and HSC expansion in MPNs by reprogramming the marrow microenvironment and activating LINE-1 retrotransposons.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Synthetic Lethal Interactions Prediction Based on Multiple Similarity Measures Fusion

Lianlian Wu, Yuqi Wen, Xiaoxi Yang, Bowei Yan, Song He, Xiaochen Bo

This paper predicts synthetic lethal gene pairs using a similarity fusion approach with k-NN classification, showing effectiveness and practicality.

Journal of Computer Science and Technology · Mar 31, 2021Peer-reviewedBioinformatics