Author

Kyla Masarik

Stony Brook School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Huichun ZhaniD· 2 shared Xiaoxi YangiD· 2 shared Fangfang ZhangiD· 1 shared Haoyi ZhengiD· 1 shared Kirsten Zheng· 1 shared Lei ZhengiD· 1 shared Sandy LeeiD· 1 shared Tameena Ahmed· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Huichun ZhanORCID

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2 papers

Recent·Most cited

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular Disease

Xiaoxi Yang, Kyla Masarik, Xiaochuan Sun, Fangfang Zhang, Kirsten Zheng, Haoyi Zheng, Huichun Zhan

This study shows that JAK2V617F-mutant hematopoiesis causes cardiac microvascular disease, and blocking MPL signaling in endocardial endothelial cells improves cardiac function.

bioRxiv · Apr 3, 2026 · PreprintCell Biology

The Immune-Modulatory Function of Megakaryocytes in the Hematopoietic Niche of Myeloproliferative Neoplasms

Sandy Lee, Xiaoxi Yang, Kyla Masarik, Tameena Ahmed, Lei Zheng, Huichun Zhan

This study shows that JAK2V617F mutant megakaryocytes drive immune dysregulation and HSC expansion in MPNs by reprogramming the marrow microenvironment and activating LINE-1 retrotransposons.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology