Andrew A. Grace

Whole-genome sequencing implicates rare, low-frequency and structural non-coding variation at the SCN5A locus in Brugada syndrome

This study identifies rare and low-frequency non-coding variants at the SCN5A locus associated with Brugada syndrome using whole-genome sequencing and functional assays.

A rare non-coding enhancer variant in SCN5A contributes to the high prevalence of Brugada syndrome in Thailand

The paper identifies a rare non-coding enhancer variant in SCN5A associated with Brugada syndrome in Thailand, showing it disrupts a transcription factor binding site and reduces sodium current.

Improved Outcome And Cost Effectiveness In Ablation Of Persistent Atrial Fibrillation Under General Anaesthetic

This study shows that general anaesthesia in persistent atrial fibrillation ablation improves clinical outcomes and is cost-effective compared to sedation.

Ablation Of Complex Fractionated Electrograms Improves Outcome In Long Standing Persistent Atrial Fibrillation

This study shows that adding complex fractionated electrogram (CFAE) ablation to pulmonary vein isolation improves freedom from atrial arrhythmia in long-standing persistent AF patients with over 30 months of AF duration.