Arie O. Verkerk

This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.

This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.

This study compares electrophysiological properties of left and right stellate ganglia neurons in mice, finding differences in resting membrane potential and minimum diastolic potential between sexes and ganglia, but similar action potential characteristics overall.

This paper redefines CPVT as a neurocardiac condition by showing RyR2 mutations affect both cardiac and neuronal function, leading to altered calcium homeostasis and increased sympathetic innervation.

This study shows WT1 regulates SCN5A expression and cardiac conduction in Brugada syndrome through a regulatory element in the RV.

The paper identifies a rare non-coding enhancer variant in SCN5A associated with Brugada syndrome in Thailand, showing it disrupts a transcription factor binding site and reduces sodium current.

This study identifies TMPRSS6 cleavage of KCNE1 as a mechanism causing arrhythmias in iron overload disease using human iPSC-derived cardiomyocytes and computational models.

The paper reclassifies a variant in KCNH2 as a low penetrant likely pathogenic variant for LQTS2 based on biophysical effects and clinical variability.

This study maps the transcriptional changes during human pacemaker cell differentiation using single-cell RNA sequencing and identifies roles for WNT and TGFβ signaling in subtype specification.