Josephine Louise Robb

Lipid droplet lipolysis in POMC neurons regulates energy homeostasis in a sex-specific manner

This study shows that lipid droplet lipolysis in POMC neurons regulates energy homeostasis, with sex-specific effects on body weight and metabolism.

Inhibition of histone lysine demethylase restores learning and memory in aged mice

This study shows that inhibiting LSD1, a histone demethylase, restores learning and memory in aged mice by reversing age-related defects in H3K4me3 dynamics and synaptic plasticity.

DGAT1-dependent lipid droplet synthesis in microglia attenuates neuroinflammatory responses to lipopolysaccharides.

This study shows DGAT1-dependent lipid droplet synthesis in microglia reduces pro-inflammatory cytokine production in response to LPS.

Immunometabolic state modulation of sequential decision making in patch-foraging mice

This study shows that systemic inflammation increases exploitative behavior in mice during patch-foraging tasks, suggesting a link between immunometabolic states and decision-making.

Microglial adipose triglyceride lipase regulates neuroinflammatory and behavioural responses to LPS

This study shows that inhibiting ATGL in microglia reduces LPS-induced inflammation and sickness behavior in mice.

Regulation of astrocyte metabolism by mitochondrial translocator protein 18kDa

This study investigates the role of TSPO in astrocyte metabolism and inflammation, finding that TSPO deficiency alters metabolic flexibility but not the inflammatory response to LPS.

Human primary astrocytes increase basal fatty acid oxidation following recurrent low glucose to maintain intracellular nucleotide levels

This study shows that human astrocytes increase fatty acid oxidation under recurrent low glucose to maintain nucleotide levels, indicating mitochondrial dysfunction in hypoglycemia response.