Klaus Benndorf

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

This study uses molecular dynamics simulations to compare ion conduction mechanisms in HCN and CNG channels, revealing differences in selectivity filter dynamics that explain their functional divergence.

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

The paper measures single HCN channel conductance at femtosiemens resolution, finding that mHCN1, mHCN3, and mHCN4 have smaller conductances than mHCN2.

Functional properties of a disease mutation for migraine in Kv2.1/6.4 channels

This study examines the biophysical effects of the L360P mutation in Kv2.1/6.4 channels, showing its impact on channel function and providing insights into migraine pathophysiology.

Bayesian inference of kinetic schemes for ion channels by Kalman filtering

This paper develops a Bayesian filter with Kalman filtering to infer kinetic schemes for ion channels, showing improved accuracy and uncertainty quantification compared to classical methods.