Author

Jana Kusch

Jena University HospitalORCID 0000-0001-7206-8133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Chris UlensiD· 1 shared Christian SattleriD· 1 shared Debanjan TewariiD· 1 shared Han SuniD· 1 shared Haoran LiuiD· 1 shared Jessica Matos Kleiz-FerreiraiD· 1 shared Klaus BenndorfiD· 1 shared Marijke BramsiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Chris UlensORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 14, 2025

Structural basis for gating inhibition by the cytoplasmic domain in HCN1 channels

Valentina Zorzini, Jessica Matos Kleiz-Ferreira, Marijke Brams…·Chris Ulens

This study uses cryo-EM to analyze HCN1 channel variants, revealing structural differences in cAMP sensitivity and auto-inhibition mechanisms between HCN1 and HCN2 isoforms.

DOI 10.1101/2025.10.14.682313

cryo-EMexperimental assay

𝕏 PostBluesky

PhysiologyProceedings of the National Academy of SciencesPeer-reviewedJan 29, 2025

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

Klaus Benndorf, Uta Enke, Debanjan Tewari…·Christian Sattler

The paper measures single HCN channel conductance at femtosiemens resolution, finding that mHCN1, mHCN3, and mHCN4 have smaller conductances than mHCN2.

7 citations

mouseelectrophysiology

𝕏 PostBluesky