Molecular BiologybioRxivPreprint
SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP Level
Juli Liu, Yucheng Zhang, Shiyong Wu…·Lei Yang
This study shows SARS-CoV-2 genes Nsp6, Nsp8, and M reduce ATP levels in hPSC-CMs, causing apoptosis and dysfunction, and identifies drugs that may counteract these effects.
DOI 10.1101/2022.01.20.477147