Author

Edward R. Simpson

Indiana University IndianapolisORCID 0000-0001-9015-9864Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amber L. MosleyiD· 1 shared Aruna B. WijeratneiD· 1 shared Cheng WangiD· 1 shared Guihong D. QiiD· 1 shared H. R. Sagara WijeratneiD· 1 shared Jonah Z. VilseckiD· 1 shared Jose F. VictorinoiD· 1 shared Juli LiuiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSystems Biology

Amber L. MosleyORCID

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2 papers

Recent·Most cited

SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP Level

Juli Liu, Yucheng Zhang, Shiyong Wu, Lei Han, Cheng Wang, Sheng Liu, Edward R. Simpson, Ying Liu, Yue Wang, Weinian Shou, Yunlong Liu, Michael Rubart, Jun Wan, Lei Yang

This study shows SARS-CoV-2 genes Nsp6, Nsp8, and M reduce ATP levels in hPSC-CMs, causing apoptosis and dysfunction, and identifies drugs that may counteract these effects.

bioRxiv · Jan 20, 2022 · PreprintMolecular Biology

Temperature sensitive Mutant Proteome Profiling: a novel tool for the characterization of the global impact of missense mutations on the proteome

Sarah A. Peck Justice, Monica P. Barron, Guihong D. Qi, H. R. Sagara Wijeratne, Jose F. Victorino, Edward R. Simpson, Jonah Z. Vilseck, Aruna B. Wijeratne, Amber L. Mosley

This paper introduces TeMPP, a method using mass spectrometry to analyze the impact of missense mutations on protein stability and interactions, revealing mechanistic insights not obtainable through transcriptome or proteome analysis alone.

Journal of Biological Chemistry · Sep 2, 2020Peer-reviewedSystems Biology