SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP Level
Juli Liu, Yucheng Zhang, Shiyong Wu, Lei Han, Cheng Wang, Sheng Liu, Edward R. Simpson, Ying Liu, Yue Wang, Weinian Shou, Yunlong Liu, Michael Rubart, Jun Wan, Lei Yang
This study shows SARS-CoV-2 genes Nsp6, Nsp8, and M reduce ATP levels in hPSC-CMs, causing apoptosis and dysfunction, and identifies drugs that may counteract these effects.
bioRxiv · Jan 20, 2022 · PreprintMolecular Biology