Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis
Jackson T. Baumgartner, Lukas A. Varga, Jackson T. Calhoun, Vitor Hugo Balasco Serrão, Sarah Loerch, Shaun M. K. McKinnie
This study solves the structure of a selective bromoperoxidase and identifies mechanisms for site-selective halogenation through distinct pockets and a camera shutter mechanism.
bioRxiv · Oct 24, 2025 · PreprintBiochemistry