NADPH phosphatase activity of Mesh1 controls sleep in Drosophila
Taro Ishikawa, Yohei Nitta, Jiro Osaka, Takanari Nemoto, Doshun Ito, Ryosuke Sasaki, Shouta Nonoyama, Akira Oikawa, Atsushi Sugie, Takashi Suzuki, Shinji Masuda
This study shows that the NADPH phosphatase activity of Drosophila Mesh1, specifically the W138 residue, is essential for normal sleep regulation.
bioRxiv · Dec 16, 2025 · PreprintMolecular Biology