Gaia Tavosanis

Modeling AP2M1 Developmental and Epileptic Encephalopathy in Drosophila

This study models AP2M1-DEE in Drosophila, finding heat-sensitive paralysis, altered neuron morphology, and seizure resistance, suggesting developmental defects over synaptic dysfunction.

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution

This paper demonstrates three-photon in vivo imaging in the mouse medial prefrontal cortex to achieve sub-cellular resolution of neuronal and glial activity at unprecedented depths.

Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body

The paper shows that different Kenyon cell types in Drosophila mushroom bodies encode odours for categorisation and discrimination based on ethological relevance.

Lipid Disbalance Affects Neuronal Dendrite Growth and Maintenance in a Human Ceramide Synthase Disease Model

The paper shows that lipid imbalances in a Drosophila model of PME8 cause dendrite loss and that restoring specific ceramides while reducing bioactive lipids rescues the phenotype.

A quantitative model of sporadic axonal degeneration in the Drosophila visual system

This paper develops a Drosophila model of axonal degeneration, showing that light exposure causes progressive degeneration without apoptosis, and that synaptic loss precedes degeneration, with postsynaptic signaling required to maintain axonal structure.

Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation

This study shows that memory consolidation in Drosophila involves structural and functional reorganization of a specific neural circuit in the mushroom body.

Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction

The paper investigates dendrite development in Drosophila c1vpda neurons, showing that sequential growth and stochastic retraction balance structural and functional requirements.

The branching code: a model of actin-driven dendrite arborisation

The paper develops a computational model to explain dendrite branchlet morphology in Drosophila neurons by analyzing actin-modulatory protein roles and dynamics.

A developmental stretch-and-fill process that optimises dendritic wiring

The paper develops a mathematical model of dendritic growth that optimizes wiring efficiency and space-filling through two complementary strategies.