The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters
Xinya Huang, Yan Kuang, Meili Li, Minjie Hong, Demin Xu, Jiewei Cheng, Tongtong Huang, Xianlei Sun, Wenkai Wang, Ying Zhou, Xuezhu Feng, Xiangyang Chen, Chengming Zhu, Shouhong Guang
The paper shows that TAF-12 is required for piRNA transcription in C. elegans by recruiting transcription factors and machinery to H3K27me3-enriched regions.
bioRxiv · Apr 11, 2025 · PreprintGenetics