Shouhong Guang

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

This study identifies SET-19 as a somatic H3K23 methyltransferase in C. elegans and shows its role in gene repression through chromatin modifications.

This study investigates the role of GTBP-1 in heat stress response in C. elegans germline, showing its involvement in stress granule formation and reproductive homeostasis.

This study identifies SET-24, a catalytically inactive SET domain protein in C. elegans, as essential for maintaining transgenerational epigenetic memory through its interaction with HCF-1 and regulation of H3K4me3 levels.

The paper identifies two novel proteins, EGC-2 and EGC-3, that are essential for E granule assembly and small RNA homeostasis in C. elegans using TurboID-based proximity labeling and RNAi screening.

This study shows that rRNA intermediates influence nucleolar structure in C. elegans by altering protein distribution and causing architectural changes.

The paper shows that spatial clustering of piRNA genes in nematodes enhances transcription through phase separation involving UAD-2 and the SUMO regulatory factors GEI-17 and TOFU-3.

The paper introduces R-LARIAT, a red light-induced protein clustering system that inhibits protein functions in HeLa cells by trapping GFP-tagged proteins, demonstrating high efficiency and stability.

The paper shows that TAF-12 is required for piRNA transcription in C. elegans by recruiting transcription factors and machinery to H3K27me3-enriched regions.

The paper identifies subcompartments within C. elegans germ granules and maps perinuclear proteins to specific regions, revealing a novel D granule and the role of MIP-1/EDDG-1 in germ granule architecture.

The paper identifies a new subnuclear organelle called the nucleolar stress body (NoSB) in C. elegans, formed through the NOSR-1/NUMR-1 axis in response to nucleolar stress.

The paper identifies peri-centrosomal localization of siRNAs in C. elegans using NRDE-3 as a reporter, showing dependence on 22G siRNAs and centrosomal components.

xQTLbiolinks is a tool for integrative analysis of molecular QTLs, enabling retrieval, preprocessing, and colocalization with GWAS data to identify disease-risk genes.

The paper identifies a nematode gene acquired via horizontal gene transfer from bacteria that enhances stress resilience by enabling L-rhamnose biosynthesis for cuticle integrity.

The paper systematically characterizes chromodomain proteins in C. elegans, identifying CEC-5 as an H3K9me1/2 reader that regulates aging through interactions with MET-2.

The paper identifies a ZTF-7/RPS-2 complex involved in C. elegans' response to cold-warm temperature changes by regulating RNA exosome localization.

This study shows that mutations in H3K9me1/2 methyltransferase genes synergistically extend lifespan in C. elegans daf-2 mutants, enhancing stress resistance through DAF-16 activation.

This study maps the interaction network of the C. elegans PICS complex and reveals structural and functional mechanisms underlying piRNA biogenesis and cell division.

The paper identifies factors involved in risiRNA generation in C. elegans and shows their role in rRNA surveillance through exosome and nucleolar RNAi mechanisms.

The paper identifies CDE-1 as a factor that suppresses risiRNA production by polyuridylating and degrading 26S rRNA in C. elegans.

The paper identifies the USTC complex as essential for piRNA transcription in C. elegans, revealing its role in genome defense through specific binding to piRNA clusters.

The paper identifies a PICS complex involved in piRNA processing and chromosome segregation in C. elegans, with distinct localization and function in different cellular contexts.

The paper identifies WAGO-4, a cytoplasmic Argonaute protein, as essential for the inheritance of RNAi in C. elegans, showing its role in translocating to the germline and binding 22G-RNAs.