NeuroscienceMolecular NeurodegenerationPeer-reviewed
APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney…·Lance A. Johnson
This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.