Holden C. Williams

This study investigates how tau pathology affects metabolism and excitatory activity in mouse models, finding that it preserves glucose tolerance and shifts metabolic flux toward glutamate synthesis.

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.