Author

Adeline E. Walsh

University of KentuckyORCID 0000-0002-2425-2945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Organism:mouse· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Holden C. WilliamsiD· 3 shared Josh M. MorgantiiD· 3 shared Lance A. JohnsoniD· 3 shared Nicholas A. DevanneyiD· 3 shared Amy A. Gorman· 2 shared Cathryn T SmithiD· 2 shared Danielle S. Goulding· 2 shared Elizabeth J. Allenger· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Holden C. WilliamsORCID

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3 papers

Recent·Most cited

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T Smith, James L. Schwartz, Adeline E. Walsh, Harrison A. Clarke, Danielle S. Goulding, Elizabeth J. Allenger, Gabriella Morillo Segovia, Cassi M. Friday, Amy A. Gorman, Tara R. Hawkinson, Steven M. MacLean, Holden C. Williams, , Lance A. Johnson

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

Cell Reports · Mar 1, 2023Peer-reviewedNeuroscience

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac, Shannon L. Macauley, Steven Estus, Julia TCW, Lance A. Johnson, Josh M. Morganti

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

bioRxiv · Feb 6, 2023 · PreprintNeuroscience

APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, D.J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E.A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. Golden, Cathryn T Smith, , Lance A. Johnson

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.

Molecular Neurodegeneration · Sep 6, 2021Peer-reviewedNeuroscience