Self-organization of spermatogenic wave coordinates sustained sperm production in the mouse testis
Toshiyuki Sato, Yuting I. Li, David J. Jörg, Mitsuru Komeya, Hiroyuki Yamanaka, Hiroko Nakamura, Kodai Hirano, Yohei Kondo, Kazuhiro Aoki, Masahide Takahashi, Hiroki Nakata, Hiroshi Kimura, Takehiko Ogawa, Benjamin D. Simons, Shosei Yoshida
The paper uses live imaging and mathematical modeling to show how self-organization of cell turnover in mouse testes sustains sperm production through phase waves and retinoic acid signaling.
bioRxiv · Nov 3, 2024 · PreprintDevelopmental Biology