Author

Hermann Broder Schmidt

Stanford MedicineORCID 0000-0002-0750-8419Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaron D. GitleriD· 1 shared Adam BrineriD· 1 shared Alex S. HolehouseiD· 1 shared Beryl B. CummingsiD· 1 shared Björn OskarssoniD· 1 shared Bradley F. BoeveiD· 1 shared Caitlin M. RodrigueziD· 1 shared Caiwei GuoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Aaron D. GitlerORCID

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2 papers

Recent·Most cited

C9ORF72-derived polyGR polypeptides disrupt passive nucleocytoplasmic transport by tuning protein affinity for the nuclear pore barrier

Daniel A. Solomon, Ryan J. Emenecker, Marie-Therese Salcher-Konrad, Sofia Marina Konstantinidou, O. H. Houghton, Eleanor Wycherley, Seoungjun Lee, Niamh Louise O’Brien, Juan Alcalde, Ines Lourenco Cabaco, Marc‐David Ruepp, Hermann Broder Schmidt, Alex S. Holehouse, Sarah Mizielinska

This study shows how polyGR polypeptides from C9ORF72 disrupt nucleocytoplasmic transport by altering protein affinity for the nuclear pore FG barrier, leading to biphasic transport outcomes and protein aggregation.

bioRxiv · Mar 17, 2026 · PreprintCell Biology

TDP-43 represses cryptic exon inclusion in FTD/ALS gene UNC13A

X. Rosa Ma, Mercedes Prudencio, Yuka Mitsuhashi Koike, Sarat C. Vatsavayai, Garam Kım, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, Hermann Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, , Aaron D. Gitler

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.

Nature · Feb 23, 2022Peer-reviewedNeuroscience