Author

Sarat C. Vatsavayai

University of California, San FranciscoORCID 0000-0002-1889-0019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

William W. SeeleyiD· 3 shared Aaron D. GitleriD· 2 shared Caiwei GuoiD· 2 shared Eric M. GreeniD· 2 shared Georgiana MilleriD· 2 shared Leonard PetrucelliiD· 2 shared Shila Mekhoubad· 2 shared Tetsuya AkiyamaiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

William W. SeeleyORCID

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3 papers

Recent·Most cited

Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD

Arnar Breevoort, Dimitar Ivanov, Liam Horan-Portelance, Alissa L. Nana, Sarat C. Vatsavayai, Àlex Tudoras, Jenelle L. Wallace, Jingwen W Ding, Felipe L. Pereira, Kristen Fernhoff, Maria Luisa Gorno‐Tempini, Salvatore Spina, Jennifer S. Yokoyama, Howard J. Rosen, Lea T. Grinberg, , Alex A. Pollen

The paper identifies molecular subtypes of neurons in the frontoinsular cortex and links specific gene expression patterns to neuronal vulnerability in FTD.

bioRxiv · Jul 14, 2026 · PreprintNeuroscience

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

Caiwei Guo, Kuchuan Chen, Sarat C. Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell, Shannon Zhen, Shila Mekhoubad, Ryan D. Morrie, Georgiana Miller, Dragana Ilic, , Aaron D. Gitler

This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.

Science Translational Medicine · Jun 3, 2026Peer-reviewedNeuroscience

TDP-43 represses cryptic exon inclusion in FTD/ALS gene UNC13A

X. Rosa Ma, Mercedes Prudencio, Yuka Mitsuhashi Koike, Sarat C. Vatsavayai, Garam Kım, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, Hermann Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, , Aaron D. Gitler

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.

Nature · Feb 23, 2022Peer-reviewedNeuroscience