Author

Sofia Marina Konstantinidou

King's College LondonORCID 0000-0002-6088-3832Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandra GranataiD· 1 shared Alex S. HolehouseiD· 1 shared Alexandra V. PokhilkoiD· 1 shared Anna WilliamsiD· 1 shared Daniel A. Solomon· 1 shared Eleanor Wycherley· 1 shared Erin Boland· 1 shared Gaia BrezzoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alessandra GranataORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 17, 2026

C9ORF72-derived polyGR polypeptides disrupt passive nucleocytoplasmic transport by tuning protein affinity for the nuclear pore barrier

Daniel A. Solomon, Ryan J. Emenecker, Marie-Therese Salcher-Konrad…·Sarah Mizielinska

This study shows how polyGR polypeptides from C9ORF72 disrupt nucleocytoplasmic transport by altering protein affinity for the nuclear pore FG barrier, leading to biphasic transport outcomes and protein aggregation.

1 citation

humanproteomics

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NeurosciencebioRxivPreprintApr 4, 2025

Cerebral small vessel disease due to Col4a1 mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding.

Gaia Brezzo, Alexandra V. Pokhilko, Jon Moss…·Karen J. Horsburgh

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

DOI 10.1101/2025.04.04.647207

mouseexperimental assay

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