Helixer--de novo Prediction of Primary Eukaryotic Gene Models Combining Deep Learning and a Hidden Markov Model
Felix Holst, Anthony Bolger, Felicitas Kindel, Christopher Günther, Janina Maß, Sebastian ST Triesch, Niklas Kiel, Nima P. Saadat, Oliver Ebenhöh, Björn Usadel, Rainer Schwacke, Andreas P.M. Weber, Marie Bolger, Alisandra K. Denton
Helixer, a hybrid convolutional/bLSTM network with a hidden Markov model post-processor, predicts eukaryotic primary gene models from DNA alone, outscoring GenemarkES and AUGUSTUS on most species.
Nature Methods · Nov 24, 2025Peer-reviewedBioinformatics✦ In-depth digest