Author

Michael Kugler

Ludwig-Maximilians-Universität MünchenORCID 0000-0002-0752-9682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

Christophe JungiD· 1 shared Filiz KuybuiD· 1 shared Heng-Jun CuiiD· 1 shared Jia‐Xuan CheniD· 1 shared Karl‐Peter HopfneriD· 1 shared Katja LammensiD· 1 shared Yilan FaniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Christophe JungORCID

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1 paper

Recent·Most cited

Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex

Yilan Fan, Filiz Kuybu, Heng-Jun Cui, Katja Lammens, Jia‐Xuan Chen, Michael Kugler, Christophe Jung, Karl‐Peter Hopfner

This study determines cryo-EM structures of human MRN complex bound to DNA and TRF2, revealing how MRN senses DNA ends and separates sensing from nuclease activity.

bioRxiv · Mar 14, 2025 · PreprintBiochemistry