BiochemistrybioRxivPreprint
Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex
Yilan Fan, Filiz Kuybu, Heng-Jun Cui…·Karl‐Peter Hopfner
This study determines cryo-EM structures of human MRN complex bound to DNA and TRF2, revealing how MRN senses DNA ends and separates sensing from nuclease activity.
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