Replication-stress response shapes Leishmania genome plasticity through non-equivalent RAD9 and HUS1 functions.
Ricardo Obonaga, Jennifer Ann Black, Stela Virgilio, Richard McCulloch, Jeziel Dener Damasceno, Luiz Ricardo Orsini Tosi
This study shows that HUS1 and RAD9 subunits of the 9-1-1 checkpoint clamp have opposing roles in shaping genome plasticity in Leishmania major through distinct replication-stress responses and genome remodelling patterns.
bioRxiv · Nov 10, 2026 · PreprintMolecular Biology