Jeziel D. Damasceno

This study shows that HUS1 and RAD9 subunits of the 9-1-1 checkpoint clamp have opposing roles in shaping genome plasticity in Leishmania major through distinct replication-stress responses and genome remodelling patterns.

This study shows that ATR modulates DNA replication timing in Leishmania major, promoting genome stability by preventing replication stress-induced chromosome instability.

This study shows that R-loops and RNase H1 regulate DNA replication timing and genome stability in Leishmania, linking R-loop homeostasis to chromosome size and replication order.

This study maps RPA1 and RAD9 in Leishmania to understand replication stress response, showing stress hotspots correlate with replication initiation and transcription termination.

The paper analyzes aneuploidy patterns across 866 Trypanosomatid isolates, finding aneuploidies are ancestral and an ancient duplication is maintained in some species.